Sakura Dormitory is a dorm of the high school affiliated with Suimei University of the Arts (often shortened as Suiko), which hosts the strangest, most trouble-making students. After being kicked out of the normal dorm for keeping a stray cat, Sorata Kanda moves into Sakura Dormitory. As he starts to get used to the life in the dorm, Mashiro Shiina, a world famous artist who cannot even take care of her daily life, moves in. Sorata is forced to become Mashiro's handler. The story is about their daily lives as well as mental growth.